Acute Kidney Injury and Intestinal Dysbiosis

Within the multiple communication pathways of intestine-kidney axis, one most important is interaction between commensals intestinal microbiome, through production short-chain fatty acids, and segments nephron. These interactions maintain a perfect environmental balance. During AKI, there are negative repercussions in all organs, systemic interconnection related part to intense inflammation uremic environment that this syndrome generates. For example, intestine, microbiome severely affected, with decrease benign bacteria promote anti-inflammatory effects an increase negative, pro-inflammatory bacteria. This scenario dysbiosis widens inflammatory loop favors worsening kidney function probability dying. It possible manipulation probiotics, prebiotics symbiotics reasonable therapeutic goal for AKI.